Abstract
The first example of tripeptide inhibitors of farnesyltransferase with sub-micromolar inhibition activity was developed based on the fact that CVFM is not a substrate for farnesyltransferase.
MeSH terms
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Alkyl and Aryl Transferases / antagonists & inhibitors*
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Amino Acid Sequence
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Enzyme Inhibitors / chemical synthesis*
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Enzyme Inhibitors / chemistry
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Enzyme Inhibitors / pharmacology*
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Farnesyltranstransferase
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Oligopeptides / chemical synthesis*
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Oligopeptides / chemistry
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Oligopeptides / pharmacology*
Substances
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Enzyme Inhibitors
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Oligopeptides
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Alkyl and Aryl Transferases
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Farnesyltranstransferase